Mentoring Vision Research in Oklahoma
COBRE
Department of Ophthalmology
University of Oklahoma Health Sciences Center
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John Ash, Ph.D.

Wei Cao, Ph.D.

Michael Ihnat, Ph.D.

Yun Le, Ph.D.

Raju Rajala, Ph.D.
PROMISING JUNIOR INVESTIGATOR
YUN LE, PH.D.


Dr. Yun Le was a post-doctoral fellow and research associate in the laboratory of Dr. Brian Sauer, who is one of the pioneers in the development and application of Cre-lox technology for conditional gene knockout. Dr. Le is an expert in this technology and has published several nice original papers and reviews in this area. For the past year, he has collaborated with Dr. Anderson to develop transgenic mice expressing Cre driven by the photoreceptor cell specific opsin promoter. In his independent research project, Dr. Le will study the role of key signaling molecules in the retinal pigment epithelium (RPE), a monolayer of cells that is essential for photoreceptor survival. Using the Cre-lox approach, Dr. Le will be in a unique position to investigate mechanisms of inherited retinal degenerations in mouse models of human diseases. Dr. Le has received an OCAST grant.

COBRE Research Project